Selective loss of microvesicles is a major issue of the differential centrifugation isolation protocols
Abstract Microvesicles (MVs) are large extracellular vesicles differing in size, cargo and composition that share a common mechanism of release from the cells through the direct outward budding of the plasma membrane.They are involved in a variety of physiological and pathological conditions and represent promising biomarkers for diseases.MV hetero